MaghrebDataLibMedV2, Main, Exploration, bibRecord, 000160

Factor V Leiden, Prothrombin 20210G>A, MTHFR 677C>T and 1298A>C, and Homocysteinemia in Tunisian Blood Donors

Identifieur interne : 000160 ( Main/Exploration ); précédent : 000159; suivant : 000161

Factor V Leiden, Prothrombin 20210G>A, MTHFR 677C>T and 1298A>C, and Homocysteinemia in Tunisian Blood Donors

Auteurs : Samira Hadhri ; Mohamed Ben Rejab ; Hajer Guedria ; Lamia Ifa ; Noureddine Chatti ; Hadef Skouri

Source :

Journal of Clinical Laboratory Analysis [ 0887-8013 ] ; 2012.

RBID : PMC:6807485

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse en composantes principales (MeSH), Donneurs de sang (statistiques et données numériques), Femelle (MeSH), Fréquence d'allèle (MeSH), Humains (MeSH), Hyperhomocystéinémie (enzymologie), Hyperhomocystéinémie (génétique), Hyperhomocystéinémie (épidémiologie), Methylenetetrahydrofolate reductase (NADPH2) (génétique), Mâle (MeSH), Polymorphisme de nucléotide simple (MeSH), Polymorphisme de restriction (MeSH), Proaccélérine (génétique), Prothrombine (génétique), Réaction de polymérisation en chaîne (MeSH), Statistique non paramétrique (MeSH), Tunisie (épidémiologie).
MESH :
- enzymologie : Hyperhomocystéinémie.
- génétique : Hyperhomocystéinémie, Methylenetetrahydrofolate reductase (NADPH2), Proaccélérine, Prothrombine.
- statistiques et données numériques : Donneurs de sang.
- épidémiologie : Hyperhomocystéinémie, Tunisie.
- Adulte, Adulte d'âge moyen, Analyse en composantes principales, Femelle, Fréquence d'allèle, Humains, Mâle, Polymorphisme de nucléotide simple, Polymorphisme de restriction, Réaction de polymérisation en chaîne, Statistique non paramétrique.
Wicri :
- geographic : Tunisie.

English descriptors

KwdEn :
- Adult (MeSH), Blood Donors (statistics & numerical data), Factor V (genetics), Female (MeSH), Gene Frequency (MeSH), Humans (MeSH), Hyperhomocysteinemia (enzymology), Hyperhomocysteinemia (epidemiology), Hyperhomocysteinemia (genetics), Male (MeSH), Methylenetetrahydrofolate Reductase (NADPH2) (genetics), Middle Aged (MeSH), Polymerase Chain Reaction (MeSH), Polymorphism, Restriction Fragment Length (MeSH), Polymorphism, Single Nucleotide (MeSH), Principal Component Analysis (MeSH), Prothrombin (genetics), Statistics, Nonparametric (MeSH), Tunisia (epidemiology).
MESH :
- chemical , genetics : Factor V, Methylenetetrahydrofolate Reductase (NADPH2), Prothrombin.
- geographic , epidemiology : Tunisia.
- enzymology : Hyperhomocysteinemia.
- epidemiology : Hyperhomocysteinemia.
- genetics : Hyperhomocysteinemia.
- statistics & numerical data : Blood Donors.
- Adult, Female, Gene Frequency, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide, Principal Component Analysis, Statistics, Nonparametric.

Abstract

Specific genetic conditions are known to be associated with high risk of venous thromboembolism. This genetic basis varies widely between ethnic groups. We investigated the distribution of four inherited polymorphisms in 113 unselected Tunisian blood donors by using polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) method. The allele frequencies of Factor V Leiden (FVL), prothrombin 20210G>A, methylenetetrahydrofolate reductase (MTHFR) 677C>T, and MTHFR 1298A>C mutations were 3, 0.9, 30, and 31%, respectively. The MTHFR 677C>T polymorphism was influenced by age. Twenty‐nine of the 113 blood donors demonstrated more than one genetic markers. Hyperhomocysteinemia was found in 12 subjects, and it was statistically associated to the MTHFR 677TT genotype. Principal component analysis allowed disclosing the resemblance between Mediterranean populations. Our findings may be helpful for population genetics study, and provide epidemiologic database for further studies in thrombosis field among Tunisians. J. Clin. Lab. Anal. 26:167‐173, 2012. © 2012 Wiley Periodicals, Inc.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807485

DOI: 10.1002/jcla.21506
PubMed: 22628232
PubMed Central: 6807485

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Blood Donors (statistics & numerical data)</term>
<term>Factor V (genetics)</term>
<term>Female (MeSH)</term>
<term>Gene Frequency (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hyperhomocysteinemia (enzymology)</term>
<term>Hyperhomocysteinemia (epidemiology)</term>
<term>Hyperhomocysteinemia (genetics)</term>
<term>Male (MeSH)</term>
<term>Methylenetetrahydrofolate Reductase (NADPH2) (genetics)</term>
<term>Middle Aged (MeSH)</term>
<term>Polymerase Chain Reaction (MeSH)</term>
<term>Polymorphism, Restriction Fragment Length (MeSH)</term>
<term>Polymorphism, Single Nucleotide (MeSH)</term>
<term>Principal Component Analysis (MeSH)</term>
<term>Prothrombin (genetics)</term>
<term>Statistics, Nonparametric (MeSH)</term>
<term>Tunisia (epidemiology)</term>
</keywords>
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<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse en composantes principales (MeSH)</term>
<term>Donneurs de sang (statistiques et données numériques)</term>
<term>Femelle (MeSH)</term>
<term>Fréquence d'allèle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hyperhomocystéinémie (enzymologie)</term>
<term>Hyperhomocystéinémie (génétique)</term>
<term>Hyperhomocystéinémie (épidémiologie)</term>
<term>Methylenetetrahydrofolate reductase (NADPH2) (génétique)</term>
<term>Mâle (MeSH)</term>
<term>Polymorphisme de nucléotide simple (MeSH)</term>
<term>Polymorphisme de restriction (MeSH)</term>
<term>Proaccélérine (génétique)</term>
<term>Prothrombine (génétique)</term>
<term>Réaction de polymérisation en chaîne (MeSH)</term>
<term>Statistique non paramétrique (MeSH)</term>
<term>Tunisie (épidémiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Factor V</term>
<term>Methylenetetrahydrofolate Reductase (NADPH2)</term>
<term>Prothrombin</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Tunisia</term>
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<term>Methylenetetrahydrofolate reductase (NADPH2)</term>
<term>Proaccélérine</term>
<term>Prothrombine</term>
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<term>Fréquence d'allèle</term>
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<front><div type="abstract" xml:lang="en"><p>Specific genetic conditions are known to be associated with high risk of venous thromboembolism. This genetic basis varies widely between ethnic groups. We investigated the distribution of four inherited polymorphisms in 113 unselected <styled-content style="fixed-case">T</styled-content>
unisian blood donors by using polymerase chain reaction‐restriction fragment length polymorphism (<styled-content style="fixed-case">PCR</styled-content>
‐<styled-content style="fixed-case">RFLP</styled-content>
) method. The allele frequencies of Factor V <styled-content style="fixed-case">L</styled-content>
eiden (<styled-content style="fixed-case">FVL</styled-content>
), prothrombin 20210G><styled-content style="fixed-case">A</styled-content>
, methylenetetrahydrofolate reductase (<styled-content style="fixed-case">MTHFR</styled-content>
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><styled-content style="fixed-case">T</styled-content>
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><styled-content style="fixed-case">C</styled-content>
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 677<styled-content style="fixed-case">C</styled-content>
><styled-content style="fixed-case">T</styled-content>
 polymorphism was influenced by age. Twenty‐nine of the 113 blood donors demonstrated more than one genetic markers. Hyperhomocysteinemia was found in 12 subjects, and it was statistically associated to the <styled-content style="fixed-case">MTHFR</styled-content>
 677<styled-content style="fixed-case">TT</styled-content>
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editerranean populations. Our findings may be helpful for population genetics study, and provide epidemiologic database for further studies in thrombosis field among <styled-content style="fixed-case">T</styled-content>
unisians. J. Clin. Lab. Anal. 26:167‐173, 2012. © 2012 Wiley Periodicals, Inc.</p>
</div>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Chatti, Noureddine" sort="Chatti, Noureddine" uniqKey="Chatti N" first="Noureddine" last="Chatti">Noureddine Chatti</name>
<name sortKey="Guedria, Hajer" sort="Guedria, Hajer" uniqKey="Guedria H" first="Hajer" last="Guedria">Hajer Guedria</name>
<name sortKey="Hadhri, Samira" sort="Hadhri, Samira" uniqKey="Hadhri S" first="Samira" last="Hadhri">Samira Hadhri</name>
<name sortKey="Ifa, Lamia" sort="Ifa, Lamia" uniqKey="Ifa L" first="Lamia" last="Ifa">Lamia Ifa</name>
<name sortKey="Rejab, Mohamed Ben" sort="Rejab, Mohamed Ben" uniqKey="Rejab M" first="Mohamed Ben" last="Rejab">Mohamed Ben Rejab</name>
<name sortKey="Skouri, Hadef" sort="Skouri, Hadef" uniqKey="Skouri H" first="Hadef" last="Skouri">Hadef Skouri</name>
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Factor V Leiden, Prothrombin 20210G>A, MTHFR 677C>T and 1298A>C, and Homocysteinemia in Tunisian Blood Donors

Factor V Leiden, Prothrombin 20210G>A, MTHFR 677C>T and 1298A>C, and Homocysteinemia in Tunisian Blood Donors

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur sur les données et bibliothèques médicales au Maghreb (version finale)
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